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KMID : 0378019710140100117
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New Medical Journal
1971 Volume.14 No. 10 p.117 ~ p.123
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Infuluences of Hypophysectomy on the Mast Cells in the Back and Ear Skin of Rat
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Abstract
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In this study mature male Swiss albino rats, weighing about 200gm. each, were divided into the
groups of normal, sham operation and hypophysectomy, and the groups of sham operation and hypophy
sectomy, were further subdivided into 1-, 2-, 3-, 5-, and 7- postoperative day groups, with 5 animals allocated to each these subgroups and the normal group. The author then made observations of the behavior of the mast cells in the ear and back skin of the animals, with the following results.
1. In the normal group, the overall average of mast cells was 99. 0 for the back skin and 60.2 for the ear skin. Most of the mast cells were of a rich-granule type and those of a poor-granule and a degranulated type were very scarce.
2. In the group of sham operation, the overall average of mast cells and the ratios for A, B and C type cells were similar to those in the normal group.
3. In the group of hypophysectomy, the overall average of mast cells, compared with that of the group of sham operation, showed a significant decrease ranging from 20 to 26% for the back skin in the 3-, 5-, and 7-day groups, but displayed a comparatively small decrease of about 16% for the ear skin in the groups of 3 or more post operative days. Moreover, the number of degranulated cells showed a remarkable increase in the 3-day group of hypophysectomy, and vaculoles in varying size were seen scattered in the cytoplasm.
Based on the above, it can be summed up that hypophysectomy on the Swiss albino rat begins a few days after the operation to induce notable changes such as the decreased number of mast cell, increase of degranulated cells, vacuolation, etc. As a consequence, it is presumed that such phenomena are caused by hormonal deficiency due to hypophysectomy.
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KEYWORD
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